Isolation and structure determination of a novel spiro-gamma-lactam, spiro-arogenate.

Co-accumulation of prephenate, L-arogenate, and spiro-arogenate in a mutant of Neurospora.

A mutant strain of Neurospora crassa blocked in each of the initial steps of tryptophan, tyrosine, and phenylalanine biosynthesis was previously shown to accumulate and secrete prephenate and L-arogenate (Jensen, R.A., Zamir, L.O., St. Pierre, M., Patel, N., and Pierson, D.L. (1977) J. Bacteriol. 132, 896-903). We now report the co-accumulation of yet another compound which was identified (Zami...

Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

Plants have a long history as therapeutics in the treatment of human diseases and have been a continuous source of inspiration for the development of new medicines. Among them, the genus Inula (Asteraceae) comprisesmore than 100 species, many of which are widely used in traditional medicine for a variety of biological purposes including anti-inammatory, anti-cancer and antibacterial activities...

A novel synthesis of diastereomerically pure spiro- oxindolopyrrolizidines and oxindolopyrrolidines via cycloaddition reactions of azomethine ylides

An efficient one-pot three-component procedure for the synthesis of new chiral spiro oxindolopyrrolidines/pyrrolizidines with highly regio- and diastereo-enantio, selective from 1,3-dipolar cycloaddition of azomethine ylides and chiral menthol-drived trans-cinnamic are described. The mechanism of the reaction is discussed on basis of the assignment of the absolute configuration of one of the cy...

Synthesis of a novel D-glucose-conjugated 15-crown-5 ether with a spiro ketal structure.

This paper describes a synthetic approach to a novel D-glucose-conjugated 15-crown-5 ether having a spiroketal structure starting from a 1-C-vinylated glucose derivative. The approach consists of the glycosylation of the vinylated glucose derivative to give an ethyleneoxy spacer derivative using bismuth(III) triflate, the conversion of the 1-C-vinyl group of the glucoside produced into a carbox...

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